What is dysfunctional uterine bleeding (DUB)?

Dysfunctional uterine bleeding means irregular or excessive bleeding during a menstrual or intermenstrual period.

It is dysfunctional uterine bleeding without any organic abnormalities such as pregnancy, tumor, and inflammation. The causes of dysfunctional uterine bleeding are complicated. It is also classified into cyclic ovulation bleeding and cyclic anovulatory bleeding. It is said that many of patients with cyclic anovulatory bleeding are younger or postmenopausal women.

In the light of findings in endometrial tissues, when an ovarian follicle exists without ovulating, secretion of estrogen is maintained, which is followed by bleeding caused by thickening of the uterine endometrium. This type of bleeding is regarded as dysfunctional uterine bleeding. When dysfuctional uterine bleeding occurs, enhancement of fibrinolytic phenomena in the uterine endometrium, especially an increase in plasminogen activators, is noted. As medication for dysfunctional  uterine bleeding, hormone pills (estrogenic hormon, corpus luteum hormone, and ambisextrous hormone) and antiplasmin drugs (epsilon and transamin) are used.

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