What is the mechanism of blood coagulation?

When endothelial cells in a vessel are injured, platelets gather around the site (coagulation), adhere to each other changing their forms (adhesion), and block the broken vessel temporarily. This triggers blood coagulation. Injured endothelial cells and platelets act on blood coagulation factors in blood plasma, and fibrinogen transforms into filiform fibrins, causing blood coagulation. The process of blood coagulation is attributable to two types of actions : autogenous action mainly by constituents of blood and exogenous action associated with components in the injured tissue.


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