How is Transamin used for treatment of pulmonary tuberculosis?

Sato et al. administered Transamin to 34 patients with pneumonia, bronchial ectasia, or pulmonary tuberculosis who had bloody sputum or hemoptysis, at a minimum maintenance dose of 250 mg, 3 times a day, to investigate the hemostatic effect of Transamin. The dose was increased to 1,500 mg per day when the amount of bloody sputum was large. Administration of Transamin stopped bleeding in 30 patients (88.2%). In 2 patients (5.9%), bleeding was stopped when the drug was administered, but bloody sputum recurred after a while. In the other 2 patients (5,9%), the drug had almost no effect. The drug can be administered without anxiety about adverse reactions. It is administered at a high dose at early stages, and after bleeding has stopped, the dose is reduced gradually until the administration is discontinued. When it is administered as  a preventative treatment from 3 to 4 days before a period in which patients easily have bloody sputum, such as a menstrual period, when a typhoon is approaching, or flu season, it sometimes happens that patients do not have bloody sputum at all.

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